If the conditions set out in C‑V, 15.2 are not met, it is necessary to issue a self-contained decision to refuse in order to comply with Rule 111(2). This is necessary, for example, where the numerous objections raised in the previous communications with respect to different sets of claims render unclear the grounds and the reasons for the refusal. This also applies if the applicant has made further submissions (including amendments) since the previous communication, where these do not cause the subsequent decision to be based on grounds or evidence on which the applicant has not had the opportunity to present comments. In all cases, the requirements of Art. 113(1) should be carefully considered (see also E‑X, 1).