ISPE Guidelines 10.04 apply.

For the particular case of claims for a known substance for a number of distinct medical uses, see GL/PCT‑EPO G‑II, 4.2.

When there is lack of unity, the claimed subject-matter is divided among the separate inventions. In this context the word "invention" means an invention having technical character and concerned with a technical problem within the meaning of Rule 5.1(a)(iii), which does not necessarily need to meet other requirements for patentability, such as novelty and inventive step (see GL/PCT‑EPO G-VI and GL/PCT‑EPO G-VII).

8.1 Reasoning for a lack of unity objection

8.2 Determination of the invention first mentioned in the claims